Topical issues of improving the technologies of bone implant sterilization for solving the problems of modern bioimplantology and creating innovative combined methods based on the combined effect of sterilizing factors of various physical and chemical nature are considered. The results of experimental developments of the authors, as well as data from other researchers, are presented, indicating the prospects of combined radiation technologies, the effectiveness of their use in comparison with currently used methods in medical practice. The importance of continuing further complex structural and functional studies of bone tissue for optimizing the parameters of sterilization modes under one-stage ozone and radiation exposure, as well as when using them in combined technologies, is noted. Priority tasks are formulated and methodological approaches to the practical implementation of one of the main conditions of radiation treatment - the maximum permissible, objectively controlled reduction of the dose load on tissues with ensuring their necessary sterility are proposed. Particular attention is paid to the importance of finding alternative (above) methods of sterilization, the use of which will expand the possibilities of single-stage methods and combined radiation technologies.
$^1$Physics Department, M.V. Lomonosov Moscow State University, chair of Physics High-Energy Accelerators and Radiation Medicine.\
$^2$All-Russian Scientific Research Institute of Medicinal and Aromatic Plants\
$^3$FSAI «N.N. Burdenko Neurosurgery Institute»,\
$^4$Lomonosov Moscow State University, Skobeltsyn Institute of Nuclear Physics, Moskow 119991, Russia.
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