Autowave self-organization of α spirals. Secondary structures chirality evaluation

A new concept of α-spirales formation as autowave structures is considered, according to which a polypeptide chain of proteins (a thermodynamically non-equilibrium system with a resource distributed over the entire length) can be treated as a one-dimensional active medium with a distributed free energy resource and from the second level of its formation – as a three-dimensional distributed active medium. Besides on the basis of the previously developed method of chirality degree quantitative evaluation in hierarchical structures of macromolecular systems, 800 structures of seven classes of enzymes were analysed. On the basis of this method, chirality maps of α-spirales, the secondary structures of proteins were obtained. The reliability of the maps is confirmed by real structures analysis.