Most current clinical applications of high intensity focused ultrasound in noninvasive surgery (HIFU) rely on the rapid heating of the propagation medium caused by absorption of the ultrasound wave energy, which results in thermal denaturation of tissue in the focal region of ultrasound beam. Recently, scientists from the University of Washington and Moscow State University have developed a new method to mechanically destroy tissue using pulse-periodic focused waves with high amplitude shock fronts. Such millisecond duration pulses cause ultrafast heating of tissue at the focus and explosive boiling in tissue during each of the pulses. Interaction of shock fronts with millimeter size vapor-gas cavity leads to mechanical disintegration of tissue into subcellular fragments. The efficiency of the method has already been shown in ex-vivo tissues of bovine liver and heart, as well as in porcine kidney in-vivo. In this paper, mechanically disintegrated lesions obtained in ex-vivo human and porcine kidney tissues were analyzed histologically. The results of comparative histological studies are discussed.
43.25.+y Nonlinear acoustics
1. V.A. Khokhlova, Physics Faculty, M.V. Lomonosov Moscow State University, Moscow, Russia 2. Y.-N. Wang - Center for Industrial and Medical Ultrasound, University of Washington, Seattle, WA, USA 3. S.V. Buravkov – Faculty of Fundamental Medicine, M.V. Lomonosov Moscow State University, Moscow, Russia 4. A.D. Maxwell, Department of Urology, School of Medicine, University of Washington, Seattle, WA, USA 5. T.D. Khokhlova, Department of Gastroenterology, School of Medicine, University of Washington, Seattle, WA, USA 6. D.W. Lin, Department of Urology, School of Medicine, University of Washington, Seattle, WA, USA 7. O.A. Sapozhnikov, Physics Faculty, M.V. Lomonosov Moscow State University, Moscow, Russia 8. M.R. Bailey - Center for Industrial and Medical Ultrasound, University of Washington, Seattle, WA, USA 9. G.R. Schade, Department of Urology, School of Medicine, University of Washington, Seattle, WA, USA
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